TY - BOOK AU - Azmi,Asfar S. TI - Molecular diagnostics and treatment of pancreatic cancer: : systems and network biology approaches SN - 9780124081031 U1 - 616.99437 PY - 2014/// CY - London PB - Academic Press KW - Pancreas KW - Cancer KW - Molecular diagnosis N1 - Includes bibliographical references and index; Section I. Current trends and advances in pancreatic cancer; Epidemiology, treatment, and outcome of pancreatic cancer; Advances in primary cell culture of pancreatic cancer; Multimodal therapies for pancreatic cancer; The role of Notch signaling pathway in the progression of pancreatic cancer; Section II. Gene expression profiling and bioinformatics analysis in pancreatic cancer; Bioinformatics analysis of pancreas cancer genome in high-throughput genomic technologies; Statistical analysis of high-dimensional data for pancreatic cancer; Gene expression profiling in pancreatic cancer; Genetic susceptibility and risk of pancreatic cancer; Section III. Pancreatic cancer proteomics; Proteomics in pancreatic cancer translational research; Proteomic differences and linkages between chemoresistance and metastasis of pancreatic cancer using knowledge-based pathway analysis; RNAi validation of pancreatic cancer antigens identified by cell surface proteomics; Section IV. Systems and network understanding of pancreatic cancer signaling; The significance of the feedback loops between Kras and Ink4a in pancreatic cancer; Systems biology of pancreatic cancer stem cells; Characterizing the metabolomic effects of pancreatic cancer; Prioritizing diagnostic, prognostic, and therapeutic microRNAs in pancreatic cancer : systems and network biology approaches; Section V. Systems approaches to pancreatic cancer therapeutics; Integration of protein network activation mapping technology for personalized therapy : implications for pancreatic cancer; Computational and biological evaluation of radioiodinated quinazolinone prodrug for targeting pancreatic cancer; Systems and network pharmacology strategies for pancreatic Ductal adenocarcinoma therapy : a resources review ER -